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In the present study, we aimed to evaluate the prevalence of serum IgG/IgA/IgM autoantibodies to FcεRIα in association with clinical/autoimmune parameters in patients with CSU. Then, we extended ELISA to detect circulating IgG/IgA/IgM autoantibodies to FcεRIα in the sera of CSU patients compared to controls.

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We could measure serum free IgE using YH35324 (capturing the FcεRIα part of free IgE) in the sera of asthmatics and hypothesized that this YH35324 could capture the FcεRIα binding site of FcεRIα-specific antibodies. Regarding the detection method of IgG autoantibody to FcεRIα, several different methods were reported a standardized method is still unavailable. Among autoantibodies, IgG to FcεRIα has been reported to be a major autoantibody for activating mast cells in CSU patients however, a recent report has demonstrated a higher prevalence of IgM to FcεRIα (than IgA and IgG antibodies to FcεRIα) in the sera of CSU patients. However, the prevalence or role of each autoantibody in CSU has not been fully understood.

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A-positive result to the autologous serum skin test (ASST) was related to the presence of autoantibodies in CSU. A type IIb hypersensitivity as an autoantibody-mediated mechanism was first reported in CSU. Īlthough IgE-mediated mechanism is a major one to activate mast cells, recent studies demonstrate autoimmune-mediated mechanisms in patients with CSU, especially those with more severe phenotypes. Recent guidelines recommend the measurement of serum autoantibody, IgG to thyroid peroxidase (TPO), which is related to not only thyroid diseases but also autoimmune diseases, to evaluate autoimmunity in patients with CSU. Mast cell is a key effector cell, and when activated by various triggers, it releases mediators and cytokines like histamine. The prevalence rate of CSU was reported at 0.5%-5% in the general population and has been increasing worldwide along with industrialization. The funders had no role in study design, data collection and analysis, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist.Ĭhronic spontaneous urticaria (CSU) is defined as the occurrence of wheals, angioedema, or both for more than 6 weeks due to unknown causes.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the paper and its Supporting information files.įunding: This study was supported by a grant of the Korea Health Technology R&D Project (HR16C0001) through the Korea Health Industry Development Institute, funded by the Ministry of Health & Welfare, Republic of Korea, and partly supported and provided with YH35324 by Yuhan, Seoul, Korea. Received: ApAccepted: AugPublished: August 19, 2022Ĭopyright: © 2022 Jang et al. PLoS ONE 17(8):Įditor: Cheorl-Ho Kim, Sungkyunkwan University and Samsung Advanced Institute of Health Science and Technology (SAIHST), REPUBLIC OF KOREA (2022) Detection of serum IgG autoantibodies to FcεRIα by ELISA in patients with chronic spontaneous urticaria. Citation: Jang J-H, Moon J, Yang E-M, Ryu MS, Lee Y, Ye Y-M, et al.

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